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PLINK file formats, format conversion, and quality control filtering for population genetics. Convert between VCF, BED/BIM/FAM, and PED/MAP formats, apply MAF, genotyping rate, and HWE filters using PLINK 1.9 and 2.0. Use when working with PLINK form...
Modern C# language features for .NET 10 and C# 14. Covers primary constructors, collection expressions, the field keyword, extension members, records, pattern matching, spans, and raw string literals. Load this skill when writing any new C# code, rev...
PHP 8.x modernization patterns. Use when upgrading to PHP 8.2/8.3/8.4, implementing type safety, or achieving PHPStan level 10.
.NET Aspire Testing 整合測試框架完整指南。當需要測試 .NET Aspire 分散式應用程式、設定 AppHost 測試或從 Testcontainers 遷移至 Aspire 測試時使用。涵蓋 DistributedApplicationTestingBuilder、容器生命週期管理、多服務編排、Respawn 配置與時間可測試性設計。 Keywords: aspire testing, .NET Aspire, DistributedApplicationTestingB...
This skill should be used when working with CSV files to create interactive data visualizations, generate statistical plots, analyze data distributions, create dashboards, or perform automatic data profiling. It provides comprehensive tools for explo...
Main orchestrator for the 10-gate development cycle system. Loads tasks/subtasks from PM team output and executes through implementation → devops → SRE → unit testing → fuzz testing → property testing → integration testing (write) → chaos testing (wr...
Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch,...
Review Django security audit patterns for settings and middleware. Use for auditing SECRET_KEY, DEBUG, CSRF, and auth decorators. Use proactively when reviewing Django apps (settings.py or manage.py present). Examples: - user: "Audit my Django settin...
Structure prediction using Boltz-1/Boltz-2, an open biomolecular structure predictor. Use this skill when: (1) Predicting protein complex structures, (2) Validating designed binders, (3) Need open-source alternative to AF2, (4) Predicting protein-lig...
Interact with QR Coin auctions on Base. Use when the user wants to participate in qrcoin.fun QR code auctions — check auction status, view current bids, create new bids, or contribute to existing bids. QR Coin lets you bid to display URLs on QR codes...
Assess organizational readiness for financial audits (internal or external). Map assertions to account balances, check evidence completeness, score readiness using a Red/Amber/Green framework, and generate a remediation timeline. Aligned with SOX, IF...
Assists with managing JavaScript/TypeScript monorepos using Turborepo. Use when configuring build pipelines, setting up caching, pruning workspaces for Docker, or optimizing CI/CD for monorepo projects. Trigger words: turborepo, turbo, monorepo, pipe...
Conduct comprehensive code reviews identifying bugs, security issues, performance problems, code quality concerns, and best practice violations. Use when reviewing pull requests, examining code changes, evaluating new code, assessing code quality, or...
Analyzes test suites and suggests optimal test execution order based on code change impact and project requirements. Use when optimizing CI/CD pipelines, deciding which tests to run before committing, or selecting critical tests under time constraint...
Create interactive HTML plots with plotly and bokeh for exploratory data analysis and web-based sharing of omics visualizations. Use when building zoomable, hoverable plots for data exploration or web dashboards.
Load spatial transcriptomics data from Visium, Xenium, MERFISH, Slide-seq, and other platforms using Squidpy and SpatialData. Read Space Ranger outputs, convert formats, and access spatial coordinates. Use when loading Visium, Xenium, MERFISH, or oth...
Detect antimicrobial resistance genes using AMRFinderPlus, ResFinder, and CARD. Screen isolates and metagenomes for resistance determinants. Use when characterizing resistance profiles in clinical isolates, surveillance samples, or metagenomic data.
Detect and quantify translated ORFs from Ribo-seq data including uORFs and novel ORFs using RiboCode and ORFquant. Use when identifying translated regions beyond annotated coding sequences or quantifying ORF-level translation.
Spatial analysis of cell neighborhoods and interactions in IMC data. Covers neighbor graphs, spatial statistics, and interaction testing. Use when analyzing spatial relationships between cell types, testing for neighborhood enrichment, or identifying...
Identifies high-quality leads for your product or service by analyzing your business, searching for target companies, and providing actionable contact strategies. Perfect for sales, business development, and marketing professionals.
End-to-end bisulfite sequencing workflow from FASTQ to differentially methylated regions. Covers Bismark alignment, methylation calling, and DMR detection with methylKit. Use when analyzing bisulfite sequencing data.
Performs structure-based virtual screening using AutoDock Vina 1.2 for molecular docking. Prepares receptor PDBQT files, generates ligand conformers, defines binding site boxes, and ranks compounds by predicted binding affinity. Use when screening ch...
Create publication-quality scientific figures with ggplot2 including scatter plots, boxplots, heatmaps, and multi-panel layouts. Use when creating static figures for papers, presentations, or reports in R.
Comprehensive PDF manipulation toolkit for extracting text and tables, creating new PDFs, merging/splitting documents, and handling forms. When Claude needs to fill in a PDF form or programmatically process, generate, or analyze PDF documents at scal...
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