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End-to-end neoantigen discovery from somatic variants to ranked vaccine candidates. Integrates HLA typing, MHC binding prediction, pVACtools neoantigen calling, and immunogenicity scoring. Use when identifying tumor neoantigens for personalized vacci...
Create portable bioinformatics pipelines with Workflow Description Language (WDL) using Cromwell or miniwdl execution engines. Use when running GATK best practices pipelines, working with Terra/AnVIL platforms, or building workflows for cloud executi...
Filter reads by quality scores, length, and N content using Trimmomatic and fastp. Apply sliding window trimming, remove low-quality bases from read ends, and discard reads below thresholds. Use when reads have poor quality tails or require minimum q...
Infer cell-cell communication networks from scRNA-seq data using CellChat, NicheNet, and LIANA for ligand-receptor interaction analysis. Use when inferring ligand-receptor interactions between cell types.
Common agent patterns and templates for Claude Code. Use when implementing agents to follow proven patterns for Tasks integration, quality checks, and external model invocation via claudish CLI.
Implement, review, or improve SwiftUI features using the iOS 26+ Liquid Glass API. Use when asked to adopt Liquid Glass in new SwiftUI UI, refactor an existing feature to Liquid Glass, or review Liquid Glass usage for correctness, performance, and de...
Generate images with Google Gemini 3.1 Flash Image Preview (Nano Banana 2) via inference.sh CLI. Capabilities: text-to-image, image editing, multi-image input (up to 14 images), Google Search grounding. Triggers: nano banana 2, nanobanana 2, gemini 3...
Technology stack evaluation and comparison with TCO analysis, security assessment, and ecosystem health scoring. Use when comparing frameworks, evaluating technology stacks, calculating total cost of ownership, assessing migration paths, or analyzing...
Information Security Management System auditing for ISO 27001 compliance, security control assessment, and certification support
ML engineering skill for productionizing models, building MLOps pipelines, and integrating LLMs. Covers model deployment, feature stores, drift monitoring, RAG systems, and cost optimization.
Document creation, format conversion (ODT/DOCX/PDF), mail merge, and automation with LibreOffice Writer.
When the user wants to add or optimize Twitter Card metadata for X (Twitter) link previews. Also use when the user mentions "Twitter Card," "twitter:card," "twitter:image," "twitter:title," "X preview," or "tweet preview."
Automated tech debt cleanup worker (L3). Reads codebase audit findings, applies safe auto-fixes for low-risk issues (unused imports, dead code, commented-out code, deprecated aliases). Confidence >=90% only. Creates single commit with summary.
Never commit secrets, manage credentials securely using environment variables, vaults, and Hack23 ISMS key management policy
Use when you need concrete UI/UX inputs (palette, typography, landing patterns, UX/a11y constraints) to drive design or review. Searchable UI/UX design intelligence (styles, palettes, typography, landing patterns, charts, UX/a11y guidelines + stack b...
Generate markdown documentation for a module or feature
Apply London (mock-based) and Chicago (state-based) TDD schools. Use when practicing test-driven development or choosing testing style for your context.
Move testing activities earlier in the development lifecycle to catch defects when they're cheapest to fix. Use when implementing TDD, CI/CD, or early quality practices.
Apply safe refactoring patterns to improve code structure without changing behavior. Use when cleaning up code, reducing technical debt, or improving maintainability.
Advanced visual regression testing with pixel-perfect comparison, AI-powered diff analysis, responsive design validation, and cross-browser visual consistency. Use when detecting UI regressions, validating designs, or ensuring visual consistency.
Regulatory compliance testing for GDPR, CCPA, HIPAA, SOC2, PCI-DSS and industry-specific regulations. Use when ensuring legal compliance, preparing for audits, or handling sensitive data.
WCAG 2.2 compliance testing, screen reader validation, and inclusive design verification. Use when ensuring legal compliance (ADA, Section 508), testing for disabilities, or building accessible applications for 1 billion disabled users globally.
When the user wants to optimize the title tag, page title, or SERP title. Also use when the user mentions "title tag," "meta title," "page title," "SEO title," "SERP title," "browser tab title," "title optimization," "headline for search," "title too...
Teaches agents to recognize and avoid security threats during normal activity. Covers phishing detection, credential protection, domain verification, and social engineering defense. Use when building or operating agents that access email, credential...
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