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Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequen...
Open-source CRM API for managing people, companies, notes, tasks and custom objects
Comprehensive security code review covering OWASP Top 10, authentication, authorization, and secure coding practices. Use when reviewing code for vulnerabilities or implementing security features.
Kinetic typography, logo animations, and stylized motion design skill. **Triggers when:** - User wants text animations or kinetic typography - Request involves logo reveals or title sequences - Content focuses on visual impact over education - User...
Adaptive epoch selection for Walk-Forward Optimization. TRIGGERS - WFO epoch, epoch selection, WFE optimization, overfitting epochs.
End-to-end RNA-seq workflow from FASTQ files to differential expression results. Covers QC, quantification (Salmon or STAR+featureCounts), and DESeq2 analysis with visualization. Use when running RNA-seq from FASTQ to DE results.
Run local BLAST searches using BLAST+ command-line tools. Use when running fast unlimited searches, building custom databases, performing large-scale analysis, or when NCBI servers are slow or unavailable.
Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
Sort alignment files by coordinate or read name using samtools and pysam. Use when preparing BAM files for indexing, variant calling, or paired-end analysis.
Practical guide for building safe, syntax-aware srgn CLI commands for source-code search and transformation. Use when users ask for srgn commands, scoped refactors (comments/docstrings/imports/functions), multi-file rewrites with --glob, custom tree-...
Create ASCII diagrams for markdown using graph-easy. TRIGGERS - ASCII diagram, graph-easy, architecture diagram, markdown diagram.
Maps and documents codebases of any size by orchestrating parallel subagents. Creates docs/CODEBASE_MAP.md with architecture, file purposes, dependencies, and navigation guides. Updates CLAUDE.md with a summary. Use when user says "map this codebase"...
High-performance monorepo build system with intelligent caching, task orchestration, and parallel execution for multi-package repositories and microservices.
Write clear, plain-spoken code comments and documentation that lives alongside the code. Use when writing or reviewing code that needs inline documentation—file headers, function docs, architectural decisions, or explanatory comments. Optimized for b...
Use for fastboot operations, flashing partitions, bootloader unlocking, recovery mode, or partition management. Triggers on "fastboot", "flash boot.img", "unlock bootloader", "recovery mode", "TWRP", "Magisk", "partition", "sideload", "A/B slots". WA...
Use when writing type annotations on variables. Use when TypeScript can infer the type. Use when code feels cluttered with types.
Use when designing or modifying APIs. Use when adding breaking changes. Use when clients depend on API stability.
ffmpeg audio mixing patterns for video production. Use when mixing narration with music, implementing ducking, or balancing volume levels for demos
Generate Mermaid diagrams in markdown. Triggers on: diagrams, charts, visualizations, flowcharts, sequence diagrams, architecture diagrams, ER diagrams, state machines, Gantt charts, mindmaps, C4, class diagrams, git graphs. Use when: user asks for...
Multi-PR development for large features. Stack dependent PRs, manage rebases, and get faster reviews on smaller changes. Use when creating stacked PRs.
Guide for using Beads (bd) - A memory upgrade and task management tool for AI agents.
Initialize a new Bun project with TypeScript and optimal configuration. Use when starting a new Bun project or converting a directory to a Bun project.
Supadata API via curl. Use this skill to extract transcripts from YouTube/TikTok/Instagram videos and scrape web content to markdown.
Debug and optimize Android/Gradle build performance. Use when builds are slow, investigating CI/CD performance, analyzing build scans, or identifying compilation bottlenecks.
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