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Python coding guidelines and best practices. Use when writing, reviewing, or refactoring Python code. Enforces PEP 8 style, syntax validation via py_compile, unit test execution, modern Python versions only (no EOL), uv for dependency management when...
Operate the deepbook CLI for DeepBook reads (REST/SSE), global ~/.deepbook config/account management, on-chain spot trading, top-level swap execution, balance-manager ops, and margin trading.
Manage agent memory with Membase - a decentralized, encrypted memory backup and restore system. Provides backup, restore, list, diff, status, and cleanup operations for agent memories.
Windows App Development CLI (winapp) for building, packaging, and deploying Windows applications. Use when asked to initialize Windows app projects, create MSIX packages, generate AppxManifest.xml, manage development certificates, add package identit...
Activate regulatory compliance specialist mode. Expert in SOX, GDPR, HIPAA, and PCI-DSS requirements. Use when reviewing code for compliance, implementing audit trails, data protection, or regulatory controls.
Create and optimize Dockerfiles with BuildKit, multi-stage builds, advanced caching, and security. Use when: (1) Creating new Dockerfile, (2) Optimizing existing Dockerfile, (3) Reducing image size, (4) Improving security, (5) Using Python with uv, (...
Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor bindin...
Guide for creating reusable commands via the Packmind CLI. This skill should be used when users want to create a new command that captures multi-step workflows, recipes, or task automation for distribution to CoPilot.
Use before merging PR - final gate ensuring all tests pass, review complete, CI green, and acceptance criteria verified
Request clarification when input is ambiguous. Use when user request has missing parameters, conflicting interpretations, or insufficient constraints for reliable execution.
Handle paired-end FASTQ files (R1/R2) using Biopython. Use when working with Illumina paired reads, synchronizing pairs, interleaving/deinterleaving, or filtering paired data.
Search TypeScript SYMBOLS (functions, types, classes) - NOT text. Use Glob to find files, Grep for text search, LSP for symbol search. Provides type-aware results that understand imports, exports, and relationships.
Use interactive transactions with $transaction callback for atomic operations and automatic rollback. Use when operations must succeed or fail together.
Algorithmic decision tree for when to follow plan exactly vs when to report BLOCKED - prevents scope creep and unauthorized deviations
High Performance Optimization Software for solving linear programming (LP), mixed integer linear programming (MILP), and quadratic programming (QP) problems
Expert in mise—a fast, flexible polyglot runtime and task manager. Specializes in tool version management, environment variable control, task automation, and shell integration across development workflows.
This skill teaches how to access GitHub's REST and GraphQL APIs via gh api for inline PR comments, review threads, and data not available through standard gh commands. Use this when you need PR review comments, thread status, or other GitHub data tha...
Managing local .NET tools with dotnet-tools.json for consistent tooling across development environments and CI/CD pipelines.
Local development environment with Docker Compose for PostgreSQL and other services. This skill should be used when setting up local infrastructure, managing development databases, or configuring containerized services.
HTMLCSStoImage API via curl. Use this skill to generate images from HTML/CSS or capture screenshots of web pages.
This skill should be used when the user asks to "lint bash script", "run shellcheck", "format shell script", "use shfmt", "fix shellcheck errors", or mentions shell script linting, formatting, code quality, or pre-commit hooks for bash.
Windows App Development CLI (winapp) for building, packaging, and deploying Windows applications. Use when asked to initialize Windows app projects, create MSIX packages, generate AppxManifest.xml, manage development certificates, add package identit...
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