This skill provides a complete and streamlined workflow for performing methylation variability and epigenetic heterogeneity analysis from whole-genome bisulfite sequencing (WGBS) data. It is designed...
3
AI 95
differential-region-analysis
BIsnake20012/2/2026
The differential-region-analysis pipeline identifies genomic regions exhibiting significant differences in signal intensity between experimental conditions using a count-based framework and DESeq2. It...
3
AI 92
loop-annotation
BIsnake20012/2/2026
This skill annotates chromatin loops, including enhancer/promoter assignments, CTCF-peak overlap. It automatically constructs enhancer and promoter sets when missing and outputs standardized loop cate...
3
AI 92
hic-loop-calling
BIsnake20012/2/2026
This skill performs chromatin loop detection from Hi-C .mcool files using cooltools.
3
AI 91
peak-calling
BIsnake20012/2/2026
Perform peak calling for ChIP-seq or ATAC-seq data using MACS3, with intelligent parameter detection from user feedback. Use it when you want to call peaks for ChIP-seq data or ATAC-seq data.
3
AI 84
track-generation
BIsnake20012/2/2026
This skill generates normalized BigWig (.bw) tracks (and/or fold-change tracks) from BAM files for ATAC-seq and ChIP-seq visualization. It handles normalization (RPM or fold-change) and Tn5 offset cor...
3
global-methylation-profile
BIsnake20012/2/2026
This skill performs genome-wide DNA methylation profiling. It supports single-sample and multi-sample workflows to compute methylation density distributions, genomic feature distribution of the methyl...
